check their B12 status, and request it to be checked if it is not available, ensure the levels are more than 300 pmol/L and not above the recommended upper limit, recommend reducing frequency of the intervention if the levels are at the high end of normal range or above range
Capsule products are commercial supplements, not FDA-approved drugs
Glass coverslips were sterilized with 90% ethanol, air-dried and placed in six-well cell culture plates (Starstedt, Nmbrecht, Germany)
The Benoist 2014 study used the HGF/MET dimerization antagonist Hinge to block Dihexas procognitive activity in scopolamine-impaired rats, with oral Dihexa (2 mg/kg/day) reversing the scopolamine-induced Morris water maze deficit when administered alone but losing effect when co-administered with Hinge [3]
Ferroptosis is an iron-dependent, lipid peroxidation-driven cell death process characterized by glutathione (GSH) depletion and inactivation of glutathione peroxidase 4 (GPX4), leading to the accumulation of lipid peroxidation products (e.g., MDA and LPO) and cell membrane rupture, hallmark features include mitochondrial alterations (e.g., reduced cristae and increased membrane density), elevated lipid peroxidation, and dysregulated iron metabolism (Jiang et al
