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Same dose schedule, same biological effect

Consequently, UNC10088 promotes ubiquitination of the NSD2 PWWP1 domain by SCF FBXO22 in the presence of different combinations of ubiquitin-carrying enzymes (UCEs), E2s (UBE2D2, UBE2L3, UBE2R2) and the ARIH-type of RBR (ARIH1) (Fig

Because this combination is still investigational, exact dosing is managed within the trial protocol

She is also Professor of Physical Medicine and Rehabilitation at Weill Cornell Medicine and a Diplomate of the American Board of Lifestyle Medicine.