Injection: A small, quick injection is given in the muscle, typically in the upper arm or thigh
Investigators have studied how 5-Amino-1MQ treatment affects mitochondrial respiration and ATP production in laboratory-based cellular models
It is primarily used to decrease fat only in the stomach area in adults with HIV who have lipodystrophy
Observed effects in human trials Reported adverse events across the IV and oral trials included headache, fatigue, dizziness, nasopharyngitis, diarrhea, flatulence, increased appetite, nausea, and back pain
Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism