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Dosing Information Adult Dose of Hydrocodone And Acetaminophen for Moderate to Severe Pain Hydrocodone 2.5 mg-acetaminophen 325 mg per tablet, Hydrocodone 5 mg-acetaminophen 325 mg per tablet Initial dose: 1 to 2 tablets every 4 to 6 hours as needed for pain Maximum dose: 8 tablets/24 hours Hydrocodone 7.5 mg-acetaminophen 325 mg, Hydrocodone 10 mg-acetaminophen 325 mg per tablet Initial dose: 1 tablet every 4 to 6 hours as needed for pain Maximum dose: 6 tablets/24 hours Hydrocodone 7.5 mg-acetaminophen 325 mg per 15 mL oral solution Initial dose: 15 mL every 4 to 6 hours as needed for pain Maximum dose: 90 mL/24 hours Hydrocodone 10 mg-acetaminophen 300 mg per 15 mL oral solution Initial dose: 11.25 mL every 4 to 6 hours as needed for pain Maximum dose: 67.5 mL/24 hours Comments: Doses should be individually titrated to provide adequate analgesia while minimizing adverse reactions

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However, the rapid growth led to periodic supply constraints and drug shortage notifications across various regions, including the US