Hormesis really is, it seems, a case of what doesn't kill us makes us stronger
In experimental models of acquired epilepsy, such as chemically induced status epilepticus, there are clear signs of inflammation, reactive gliosis, and neurodegeneration (Pearson-Smith & Patel, 2017
Iron chelators such as deferoxamine (DFO), reduce the labile iron pool and prevent ferroptosis in osteoblasts and osteoclasts in preclinical models ( - axis under oxidative or diabetic conditions ( Multiple bioactive compounds, including icariin, mangiferin, fraxin, poliumoside, picein, maresin-1, vitamin K2, and vitamin D analogs, promote osteogenic differentiation and suppress ferroptosis through activation of Nrf2/HO-1 signaling and restoration of Runx2-dependent programs ( Several regulators of iron metabolism and ferroptosis have also been identified in osteoblast lineage cells
Our priori calculationbased on TNF- varianceensured adequate sensitivity for the primary powered biomarker, while clinical endpoints were exploratory and likely underpowered
Peh A, ODonnell JA, Broughton BRS, Marques FZ
