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Are GLP-1 medications being studied for Alzheimers disease

AMG 133 results in full agonism of human GLP-1R (EC 50 = 24.4 pM) and activated cynomolgus monkey and mouse GLP-1R (EC 50 of 5.7 and 123 pM, respectively)

However, some GI side effects still occur and the adherence requirement (empty stomach, etc.) requires patient education

Altogether, these findings demonstrate the necessity and sufficiency of IL astrocytic MAOB in disrupting fear extinction retrieval, leading us to investigate whether pharmacological inhibition of MAOB could provide a therapeutic strategy for PTSD

Safety evaluations in trials suggest Retatrutide is unsuitable for individuals with a family history of certain cancers