S.AbulfarajA
High temperature (38 C) induced oxidative damage to the wheat seedlings, whereas application of exogenous NO protected the seedlings from oxidative damage due to increases in GSH levels, GSH/GSSG ratio, and other components of the AsA-GSH cycle (e.g., APX and GR activities), AsA content, and activity of GSH metabolizing enzymes, including GPX and GST
Glutathione administered via IV assists in more rapid, direct, and effective delivery, especially for acute liver stress or severe depletion
While there are many antioxidant compounds in our diet, GSH (the form that we normally call l-glutathione is the reduced form of GSH) is the only antioxidant that is produced in all of our cells for the purpose of protecting us from oxidants and other toxic challenges
Glycine is also documented as being rate-limiting in GSH synthesis [25, 26]