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Journal of Investigative Dermatology , 126(8), 1869-1878

In the liver, elevated hepatic TGF-1 promotes gluconeogenesis via adenosine 35-cyclic monophosphate (cAMP)-dependent protein kinase-mediated forkhead box O (FoxO) 1 phosphorylation at serine 273, disrupting energy balance in obese, insulin-resistant mice (Pan et al

These metabolites can simultaneously drive inflammatory processes, such as oxidative stress or excitotoxicity, while activating compensatory anti-inflammatory mechanisms like IL-10 production, reflecting their inherently bidirectional immunomodulatory roles in the brain

36B4-F: 5-GCCGTGATGCCCAGGGAAGACA