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Elevated levels of MDA have been observed in iron-overloaded thalassemia patients with low bone mineral density (BMD), and supplementation with melatonin (20 mg/day for 12 months) significantly reduced MDA levels while improving lumbar spine BMD (157)

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It is possible that genetic deletions affecting a large number of cells may produce more pronounced compensatory effects during development masking the effects induced by the lack of GHR in the entire brain

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2) glycohydrolases (e.g., CD38, CD73, CD157) hydrolyze NAD + and release free ADP-ribose crucial for cellular Ca2 + signaling 911