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Many individuals may notice improvements in overall skin radiance within 48 weeks, while more visible improvements in skin brightness and even-looking skin tone may take 812 weeks or longer of regular use

10.1007/s10815-022-02429-9 94 OharaM.Yoshida-KomiyaH.Ono-OkutsuM.Yamaguchi-ItoA.TakahashiT.FujimoriK

Furthermore, binding of these S100 proteins to RAGE induces reactive oxygen species formation

Gnecco JS, Brown A, Buttrey K, Ives C, Goods BA, Baugh L, Hernandez-Gordillo V, Loring M, Isaacson KB, Griffith LG (2023) Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk

While you can support your levels with high-quality, bioavailable supplements, maintaining a nutrient-rich diet and healthy lifestyle is also beneficial.