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Retatrutide's mechanism of action involves the stimulation of three crucial hormone receptors: GLP-1 (Glucagon-like peptide-1): Plays a key role in lowering blood sugar levels and promoting satiety, which helps reduce food intake

Diabetes Obes Metab, 2025

By occupying glucagon receptors, it increases energy expenditure, improves metabolic health, and slows gastric emptying

Why Phase 2 was not enough A 17.5% weight reduction at 24 weeks in 338 participants is encouraging, but it does not answer the questions regulators ask before an NDA

Another study, published in the American Journal of Ophthalmology, used health records from over 37 million people and found that GLP-1 drugs nearly doubled the five-year risk of developing optic nerve damage