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Insulinemia increased in animals that received standard food regardless of whether or not sitagliptin was administered, but those that received glucose only showed an increase in insulin concentrations when the DPP4i was also administered (Nishii et al., 2014)

Patients taking oral contraceptives may need to use backup contraception for a short time after starting or increasing the dose

Understanding that GLP-1 medications take time to reach therapeutic levels prevents discouragement during the early titration phase

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Clinical Trial Evidence The head-to-head comparison comes from the SURPASS clinical trial program for diabetes and SURMOUNT program for weight loss