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Liquiritin can promote apoptosis by regulating changes in mitochondrial membrane potential and inhibit the expression of p38 and VEGF (280)

Some of the released molecules, referred to as damage-associated molecular patterns (DAMPs) like heme and its derivatives, ATP, heat shock protein (HSP70), or interleukin-33 (IL-33), are capable of triggering the immune response, amplifying inflammation [62, 63]

But another topical ingredient gaining interest is GHK-Cu (a copper peptide often found in cosmetic products)

As such, the client tail peptides are often displaced by this WD40 loop