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Second, among GLP-1 receptor agonists, only liraglutide and dulaglutide showed increased trends in the risks of overall thyroid disorders compared with placebo and other antidiabetic drugs

Serious toxicity may affect blood, bone marrow, liver, pancreas, and brain

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Pioglitazone decreases carotid intima-media thickness independently of glycemic control in patients with type 2 diabetes mellitus: results from a controlled randomized study