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Biochemical tests for this disease may indicate elevated levels of 3-hydroxyglutaric acid and decreased excretion of C5-glutarylcarnitine in urine organic acid analysis [72, 75, 76]

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Some may experience mild injection site reactions, temporary water retention, or slight tingling in extremities

and non-oral administration of PT-141 , wherein the quantity of PT-141 administered is not sufficient to initiate the desired pharmacological response in the patient when administered as a monotherapy

If a period of clinical monitoring is undertaken, patient recall systems must be used to mitigate the risk of individuals with a potential malignancy being lost to follow up