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Hypersensitivity and Anaphylaxis Severe allergic reactions including angioedema and anaphylaxis have been rarely reported

The majority of events were reported as diabetic retinopathy (4%, 2.7%, and 2.7%, respectively) and non-proliferative retinopathy (0.7%, 0%, and 0%, respectively)

When estrogen stimulates the uterine lining without progesterone's balancing effect, the lining can become abnormally thick

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