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Current status of IRI treatment: diverse research directions, yet effective intervention strategies remain insufficient IRI refers to the phenomenon where tissue or organ damage is unexpectedly exacerbated once the blood supply is restored after a period of ischemia

This gradual titration helps minimise gastrointestinal side effects such as nausea, vomiting, and diarrhoea

That said, its possible to consume too much at once , especially if youre taking a supplement without receiving a deficiency diagnosis from a doctor

PMID 15916450

FIGURE 1 2.2 Na,K-ATPase as a target of CTS and current view on the mechanisms involved in CTS effects Currently, the only receptor known to bind CTSs is Na,K-ATPase