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En el SNC, la activacin GIPR en hipotlamo amplifica la sealizacin anorexgena del GLP-1R, fenmeno observado en modelos murinos knockout condicionales

Were seeing an extraordinary pace of innovation, with GLP1-based therapiesincluding dual and triple agonists, oral agents, and longer acting formulationsmoving rapidly through latestage clinical development, said Marlon Pragnell, PhD, the ADAs Vice President of Research and Science

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Weihl CC, Connolly AM, Pestronk A (2006) Valproate may improve strength and function in patients with type III/IV spinal muscular atrophy