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The Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA) do not list antidepressants as contraindicated or requiring dose adjustment when co-prescribed with semaglutide

a) Common Side Effects Nausea Vomiting Diarrhea Constipation Stomach discomfort or bloating These side effects are usually mild or moderate and often get better as your body gets used to the medicine

Healthcare providers should assess the severity of symptoms and consider alternative treatments if persistent allergic reactions occur

Marzullo P, Daffara T, Mele C, Zavattaro M, Ferrero A, Caputo M, et al

1), 2180-LB (2025)