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Dual inhibition of sglt2 and dpp-4 promotes natriuresis and improves glomerular hemodynamic abnorMalities in kk/ta-ins2(Akita) mice with progressive diabetic kidney disease

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In hereditary or acquired metabolic defects, an initial intravenous bolus of 50 mg/kg may be administered over two to three minutes, followed by maintenance doses of 50 mg/kg every six hours or continuous infusion to achieve a total daily exposure of up to 300 mg/kg in critical illness