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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy (vol 19, pg 4861, 2010)
Since sleep regulates the brains clearance of metabolic toxins such as tau and A-42 peptides via the glymphatic system, age-related sleep disruption may impair this clearance, thereby exacerbating neuronal pathology through increased ROS production and ultimately triggering neuronal apoptosis (Xie et al., 2013
If you are looking for other ways to reduce inflammation and alleviate your arthritis pain, consider integrative medicine treatments like liposomal glutathione therapy