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Fortunately, the metabolic inflexibility conferred by this escape mechanism allows Doxycycline-resistant (DoxyR) CSCs to be more effectively targeted with many other metabolic inhibitors, including Vitamin C, which functionally blocks aerobic glycolysis

Combining this approach with CRISPR screening, we identified SLC33A1 as the major ER GSSG exporter in mammalian cells

Figure 4A and C visually present the BlandAltman plots, which graphically illustrate the agreement between the GPx-Tiron method and the GPx-DTNB and GPx-CUPRAC reference methods, respectively