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Indeed, studies in transgenic mice reveal that epithelial-specific overexpression of IGF-1R induces mammary tumors with basal-like characteristics whereas epithelial-specific down-regulation of IGF-1R produces tumor with a more claudin-low molecular profile [91]

This would allow a higher degree of efficacy when compared to tablet or capsule administration [25, 26]

Polyphenols Polyphenols, a diverse group of secondary plant metabolites, are essential in neutralizing oxidative stress in melanocytes, cells particularly prone to oxidative damage due to their role in melanin synthesis 137,138,139

Funding Statement This work was supported by Fundao para a Cincia e a TecnologiaFCT to IBIMED (UIDP/04501/2020 and UIDB/04501/2020) and LAQV/REQUIMTE (UIDB/50006/2020)

doi: 10.4172/2329-8847.1000166