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4.5 Synthesis and clinical perspective The interplay between epithelial dysfunction, immune cell activation, metabolic rewiring, and DAMP release creates a self-sustaining cycle that underlies asthma pathogenesis

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doi: 10.3389/fphys.2026.1781613 Received 06 January 2026 Revised 25 March 2026 Accepted 06 April 2026 Published 23 April 2026 Volume 17 - 2026 Edited by David Cristbal Andrade, University of Antofagasta, Chile Reviewed by Srinivasan Ramachandran, University of California, San Diego, United States Jian Chen, Shanghai University of Traditional Chinese Medicine, China Updates Copyright 2026 Xin, Yang, Wang, Ma and Jing

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