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Personally, I decided to try it as a transition product alternating with my tretinoin to get my skin used to daily retinoid use (basically, I wanted to level up with my tretinoin, to be able to apply it every day)

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it is not drug approval for any indication and does not constitute a finding of therapeutic efficacy

Fortunately, medicinal plants, such as Gynostemma pentaphyllum , may activate AMPK and provide some of the same metabolic benefits as metformin (Yoo 2016)

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