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This activation enhanced host antioxidant capacity and mitigated postpartum oxidative stress 86,87

combined single-cell RNA sequencing and population-level genetic analyses to reveal two key chondrocyte subpopulations, inflammatory and fibrocartilage chondrocytes, that are expanded in hand OA and enriched for ferroptosis-related and inflammatory pathways, with elevated expression of FTH1, implicating iron overload in OA pathogenesis (Li H

This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38

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