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Peer review Peer review information Nature Reviews Nephrology thanks Lin Sun, Mattias Carlstrom and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Maintaining a desirable level of homocysteine is one of the leading biomarkers for the maintenance of good cardiovascular health

The majority of the remaining nitrogen, approximately 40% to 70% of what is ingested, is eliminated via urine (Cole and Todd, 2009)

Russell MD, Abdelhamid Ahmed AH, Feng Z, Shonka DC, Karcioglu AS, Iwata AJ, Kyriazidis N, Siddiqui SH, Athni TS, Park JC, Wirth LJ, Zafereo ME , Randolph GW