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These peptides exert their effects by binding to melanocortin receptors located throughout the brain and nervous system

587 For example, TF and TFR2 expression are upregulated in dopaminergic neurons in PD brains, and downregulated TFR expression has also been linked to the prevention of dopaminergic neuron degeneration

This study is limited by its retrospective nature, by incomplete blinding of both patients and treaters, and by the uniquely refractory patient population and the intenstive behavioral and pharmacological management the patients were receive simultaneously

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