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The the effects of tirzepatide on physical function in adults with overweight or obesity were evaluated in a recent meta-analysis and another separate trial The authors searched PubMed, Embase, and the Cochrane Library up to July 20, 2025 for randomized controlled trials (RCTs) comparing once-weekly tirzepatide 10 or 15 mg with placebo and reporting validated physical function outcomes

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A subgroup analysis of the PIONEER 3 study explored the glycemic effects of oral semaglutide (3, 7, and 14 mg) versus sitagliptin (100 mg) by baseline HbA 1c and also by background oral glucose-lowering therapy [70]