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The results of the IPTW and subgroup analyses confirmed those of the main analysis

Dipeptidyl peptidase (DPP)-IV is an enzyme known to trigger the catalysis of insulinotropic hormones, further abating the endogenous insulin levels and elevating the glucose levels in blood plasma

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However, an unphysiologically large postprandial release of GLP1, for example, after gastric bypass surgery (Korner et al., 2007), might reach the circumventricular organs, and DPP4resistant GLP1 receptor agonists clearly have central actions, though whether this includes action on GLP1 receptors inside the BBB or is limited to direct activation of GLP1 receptors in the circumventricular organs outside the BBB, is less clear (Adams et al., 2018