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5 Modulation of excitatory pathway Glutamate is one of the principal excitatory neurotransmitters in the CNS that plays a critical role and performs various functions such as learning, memory, synaptic plasticity, nerve degeneration, neurogenesis, and many more ( 2+ influx), kainate, and AMPA (Na + Influx) receptors, while the latter one includes G protein-coupled receptors that activate the intracellular cascade ( + and Na + ions, respectively, which leads to the imbalance of excitatory and inhibitory pathways and therefore, these two receptors represent key clinical research targets ( Zizyphi Spinosi Semen (ZSS) is a medicinal plant widely used in Chinese medicine for the treatment of various diseases, including insomnia and some other psychiatric disorders (Zhao et al., 2016)
