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Several factors may contribute to allergic reactions to Wegovy: Active ingredient sensitivity : Hypersensitivity to semaglutide itself may occur, though anti-drug antibodies are uncommon according to clinical studies [1] Excipient reactions : The UK formulation contains inactive ingredients such as disodium phosphate dihydrate, sodium chloride, and pH adjusters, which could potentially trigger hypersensitivity in some individuals [1] Injection site factors : Local reactions at the injection site are relatively common Previous allergies : While not well-established, patients with previous allergies to other medications should exercise caution and inform their healthcare provider It is worth noting that no established association between Wegovy and chronic spontaneous urticaria (hives lasting more than six weeks without identifiable trigger) has been reported in the product information