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Increased DA levels in rodent models lacking the DA transporter are linked to typical disturbances like spontaneous hyperlocomotion and altered habituation to the testing environment 14

Cell models include suspension and adherent cell lines, primary cells, co-cultures, and 3D organoid systems

In most cases, these effects dont require medical intervention

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3T3 fibroblasts were maintained in culture as described previously [24] and plated in 2 cm 2 LAB-TEK II chambered cover glass (Nunc, Thermo Fischer Scientific, Waltham, MA, USA) for 5 days, 72 h, 48 h, 24 h, and 6 h before the experiment and treated after attaching as explained before