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Using a 2-D cell culture format with monolayer Caco-2 cells, for example, it is not possible to reproduce the physiological conditions present in the intestines, such as the unique intestinal tissue morphology of villi formation and mucus production, as well as key intestinal differentiated functions including cytochrome P-450-based drug metabolism

The other class of non-peptidic agonist discovered in 2007 was Compound 2 (Cmp2

*Research chemicals are specialized substances utilized by scientists for medical and scientific research

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