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Strom BL, Schinnar R, Apter AJ, Margolis DJ, Lautenbach E, Hennessy SCE, et al

Transforming Fusions of Fgfr and Tacc Genes in Human Glioblastoma

CAFs play a critical role in tumor progression and drug resistance by secreting growth factors and cytokines that promote tumor cell proliferation and migration

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However, contrary to expectations, the deletion of the Nfe2l2 gene had a moderate impact on the course of the disease in SOD1 G93A mice and negatively affected only a few Nrf2-regulated antioxidant enzymes, thus suggesting that several Nrf2-target genes can also be regulated independently of Nrf2 in ALS mice [270, 271]