Blood (2013) 122(19):332230
Unlike GLS1, GLS2 is not inhibited by CB-839 or glutamate (its immediate byproduct), and can directly bind and inhibit Rac1 (Ras-related C3 botulinum toxin substrate 1), suppressing murine and human hepatocellular carcinoma cells migration and metastasis in a mouse model [205]
The medical risks of obesity
vitamin B12, vitamin D, and coeliac serology may also be considered depending on your history and examination findings Consider referral to a dermatologist if the pattern of hair loss is unusual, rapidly progressive, patchy (suggesting alopecia areata), involves eyebrows or eyelashes, or is accompanied by scalp changes such as redness, scaling, or scarring features that may indicate a condition requiring specialist assessment, as outlined in NICE CKS guidance on alopecia Consider a supervised medication switch if losartan is deemed the likely cause and an alternative agent is clinically appropriate You can also report suspected side effects directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk, which helps build the national evidence base for drug safety monitoring
it is always available
