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Titration Protocol and Dose Escalation Your dose may need to go up during the first four to five months of treatment as your body responds to the medication and you develop tolerance

Comparison with other glucose-lowering agents, comprising sulfonylurea, dipeptidyl peptidase 4 inhibitors (DPP4-I) and SGLT2i are summarized in Supplementary Material 5

Whether these effects are complementary, neutral, or potentially conflicting is not yet established through rigorous clinical trials