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This has raised concerns about the potential risks associated with using these drugs outside their approved indications

106 Two additional clinical trials are being conducted to gather more data on adverse effects in different situations of liver injury, and a phase 2 trial investigating treatment effects for MASH with fibrosis based on histological assessment is ongoing (NCT05877547)

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The experimental results showed decreased levels of intracellular cyclic adenosine monophosphate (cAMP) and inhibition of cAMP-responsive element-binding protein (CREB) phosphorylation [137]

Beyond dietary modifications, several lifestyle interventions can significantly enhance your body's GLP-1 response and improve overall metabolic health