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There is no clinical trial data specifically studying this approach, but some prescribers report anecdotally that patients maintain better long-term responses with periodic dose reductions

Intramuscular injection typically produces sharper, more intense pain during injection, followed by prolonged soreness at the site lasting several days

Ketamine is administered intravenously, but a derivative intranasal drug (esketamine [Ketanest]) has been approved for treating intractable depression

Cardiometabolic improvements across published trials include reductions in blood pressure, triglycerides, LDL-cholesterol, HbA1c, and fasting glucose

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