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Although theres limited research on this specific side effect, the experiences of many users suggest a potential link

Additionally, rapid or extreme calorie restriction often backfires: it slows metabolism, triggers muscle loss, and can actually increase your body's resistance to semaglutide's signaling by downregulating GLP-1 receptors in your gut

Patients should report persistent injection site changes, unexplained neck masses, severe gastrointestinal symptoms, or signs of pancreatitis promptly for appropriate clinical assessment and management

10.1111/j.1365-313X.2011.04757.x 194 ZacchiniM.PietriniF.MugnozzaG

While it is often associated with age, it is important to note that there are a variety of causes for this condition