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C32 and C88 in PfGrx) could not only form an intramolecular disulfide during catalysis or affect the reactivity of the active-site thiolate but also function as a resolving cysteine for trapped Grx(SSR) species (Fig

M64 and MAC-545496 are two recently identified compounds currently in preclinical development, and both target bacterial biofilm formation

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Our findings align with these previous studies, leading us to hypothesize that GSH levels are higher in the tumor tissues of chemotherapy-resistant breast cancer patients compared to chemotherapy-sensitive patients

Interestingly, under iron-rich conditions and in the absence of host influences, iron has adverse effects, including a decrease in beneficial microorganisms and an increase in bacterial metabolite levels, which in turn impairs the barrier function of intestinal epithelial cells [73]