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The pathophysiology is still unclear, with the involvement of brain iron deficiency, dysfunction in the dopaminergic and nociceptive systems and altered adenosine and glutamatergic pathways as hypotheses being investigated

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EDC/NHS chemistry was used to graft functional groups (alanine and GSH), couple therapeutic molecules (ibuprofen and dopamine) on PLG backbone and label the co-polypeptides with R6G (Fig

Selank and Semax are nootropic peptides with neurological and anxiolytic properties