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This means preserving muscle during weight loss with semaglutide may be important to reduce insulin resistance and prevent frailty in people with obesity. Haines said that more studies are needed to find the best way to lose fat but keep muscle when using GLP-1 medications.

Later in 2022, the FDA granted tirzepetide fast track designation for overweight and obesity in adults.6 To date, tirzepetide hasnt been FDA approved for weight loss (see table Current FDA-Approved Mono and Dual Agonists for details about weight management medications)

Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm - 2020 executive summary

This can be cramping, bloating, or pain

In those cases, medications like Ozempic and other GLP-1s may also be needed