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10.1111/j.1463-1326.2012.01673.x [DOI] [PubMed] [Google Scholar] Nutt, D

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Thus, synthetic peptide impurities were reconstituted in either cell culture media, or a buffer made in our laboratory that was made to mimic the Forteo product buffer (0.41 mg/mL of glacial acetic acid, 0.1 mg/mL of sodium acetate anhydrous, 45.4 mg/mL of mannitol, 3.0 mg/mL of metacresol, pH 4.0 as specified in the Forteo package insert) ( As shown in Supplementary Figure S5 , when compared to impurity peptides reconstituted in RPMI-1640 cell culture media, no difference in the T-cell response, measured by IFN- secretion was observed when compared to impurity peptides from the same manufacturing lots reconstituted in our laboratory-made product formulation buffer