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1997) and causes differential changes in expression of numerous genes associated with stress response, cell cycle, growth inhibition, cell death, cell structure, cell signalling and inflammation (Priyadarsiny et al

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To date, tirzepatide, also known as LY3298176, is the only promising dual GIP/GLP-1 receptor agonist ( in vitro ( Though the exact mechanisms underlying GLP-1/GIP synergism are unclear, some hypotheses have suggested that GIP operates directly via the CNS by reducing food intake, increasing the anorexigenic action of GLP-1, or enhancing tolerability to GLP-1R agonists ( Figure 2 )

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AOD-9604 produced no statistically significant weight loss in its only completed efficacy trial