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Nonetheless, in other studies, GPx1-deficient mice on a high fat diet were found to have hyperglycemia and attenuated insulin secretion due to defects in pancreatic -cell function owing to increased oxidative stress [98]

However, this effect was not observed in rats treated with estradiol alone

Food and Drug Administration has approved the use of L-carnitine in hemodialysis patients for the prevention and treatment of L-carnitine deficiency.2 Additionally, certain medications including anticonvulsants and nucleoside analogues used in the treatment of HIV infection, may produce a secondary L-carnitine deficiency

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