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Follow-up timing depends on clinic protocols, but initial contact within a few weeks of starting therapy and periodic checks every few months is a common model

100 Moreover, loss of nAChRs accompanies many neurodegenerative diseases, including Parkinson's disease, suggesting that declining cholinergic signaling may be a key etiological feature

While nausea and other adverse effects may diminish with continued treatment, discontinuing escalation may leave patients below their therapeutic threshold

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