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[2] This would be consistent with the odd clinical picture reported a compound that increased daytime alertness and performance in the same studies where it was said to improve night sleep [7] looks more like a modulator of state regulation than a sedative

This rigorous methodology minimizes bias and allows for accurate attribution of adverse effects to the intervention rather than background health conditions or placebo effects

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Agents that cause depletion of catecholamines from the sympathetic nerve terminals (e.g., reserpine) can also antagonize indirectly acting agents (such as tyramine) because there is a lack of catecholamines to be released

In controlled trials in heart failure patients, the incidence of hypotension in valsartan-treated patients was 5.5% compared to 1.8% in placebo-treated patients