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Mazdutide (IBI362) is an oxyntomodulin-derived dual GLP-1/glucagon receptor agonist studied for combined incretin and hepatic metabolic effects

These combinations target complementary pathways and may provide synergistic metabolic benefits

Interestingly, it was demonstrated that different compositions of the intestinal microbiota via their distinct abilities to produce SCFA might in turn affect expression of FFAR by epigenetic gene regulation (192)

This involves a negative pregnancy test before starting treatment, use of highly effective contraception throughout (noting that topiramate may reduce the efficacy of some combined hormonal contraceptives discuss suitable methods with your prescriber), and annual counselling with completion of a Risk Acknowledgement Form

10.3748/wjg.v23.i22.4112 World J