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Alternative Names: Forkhead box protein O4, Proxofim, FOXO4a, AFX, AFX1, MLLT7 FOXO4-DRI Studies and Research Data Investigations in Insulin-Linked Pathways Research indicates that FOXO proteins may operate downstream of insulin and insulin-like growth factor signaling, with potential roles in cellular growth, oxidative stress regulation, and metabolic balance

However, the core downstream target genes mediating Nrf2-regulated DR iron metabolism and lipid peroxidation lack in-depth validation, and the optimal activation strategy, long-term safety of Nrf2 pathway and its crosstalk with other ferroptosis regulatory pathways remain insufficiently studied, warranting further investigation

Advances in Experimental Medicine and Biology, 1311 , Jung, J

The Biology of Ergothioneine, an Antioxidant Nutraceutical

All data in Figures are included in this article and its Supplementary Information files